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KMID : 0378019610040020087
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New Medical Journal
1961 Volume.4 No. 2 p.87 ~ p.102
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Experimental Study in the Allergic Changes of Peripheral Nerve which is influenced by Parathyroid Gland
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Abstract
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It is well known by previous numerous works, that endocrine glands are either inhibitory or accelerating to the allergic reactions of various organ allergy.
In this paper, the influence of parathyroid gland and substance upon the allergic changes of peripheral nerve is discussed.
Rabbits, approximately 2 kg. in weight, are used for the animal study. As antigen, horse serum, 1 cc/kg, once a day, subcutaneously for 4 days, is used for sensitization.
0.1 cc/kg of horse serum is injected into sciatic nerve to induce the allergic changes in both control and sensitized group of rabbits. The nerve is examined macroscopically and microscopically, 6, 12, 24, 48 hours and 1 and 2 weeks after the injection respectively.
The animals studied are divided into 8 groups, each having nonsensitized and sensitized groups, as follows;
1) Control group of normal rabbit
2) Parathyroidectomized group
3) Parathyroid gland-implanted group
4) Postparathyruidectomy parathyroid gland-implanted group
5) Group in which parathyroid substance is given
6) Group in which parathyroid substance is given after parathyroidectomy
7) Group in which mere parathyroidectomy is done without inducing allergy
8) Group in which only parathyroid substance is given without inducing allergy
In group 1-6, changes are first seen in the epineurium and perineurium. Slight hyperemia and polys infiltration are noted in epineurium, 6 hours after re-injection. They reach maximum in 48 hours and then dissipate gradually.
Eosinophils appear somewhat later than polys. They are first seen in 12 hours and increased moderately in 24 hours. After the period, they start to decrease in number.
Fibrinoid swelling becomes severe in 48 to 72 hours, then, gets better.
Lymphcytes and monocytes appear in moderate nunIber in 48 to 72 hours.
Endothelial proliferation and vascular thickening get their peaks in 48 to 72 hours.
Necrosis of epineurium is seen in 24 to 72 hours but never becomes extensive.
In perineurium and endoneurium, hyperemia is seen in moderate degree in 24 to 48 hours and proliferation of connective tissue reveals it to be moderate in 72 hours.
Endothelial proliferation is markedly observed in hours although it starts to decrease in severity after 72 hours and becomes unable to be discerned in 1 or 2 weeks.
Necrosis of perineurium is minimal and appears late, if at all.
In sheath of Schwan, phagocytosis reaches its peak in 72 hours. Proliferation of Schwan´s cell is moderately
marked in 48 to 72 hours and then starts to decline within 2 weeks, some declining more abruptly. Demyelinization and fragmentation of axon appear slower than the inflammatory changes and are seen within a week. These changes, however, disappear in 2 weeks.
In Group 7, 8, no particular changes in sciatic nerve are obserVed. SUMMARY
1) In sensitized group. allergic changes in sciatic nerve are most severe in epineatium. Changes in myelin and axon are milder and appear later.
2) In parathyroidectomized group, the allergic changes are distinctively marked in comparison with control group. In the group in which implantation of parathyroid gland was made after parathyroidectomy, the allergic changes are less severe than merely parathyroidectomized group and more severe than the group in which parathyroid substance was administered after parathyr(jdectomy, the changes of which, however, are severe than control group.
3) Allergic changes in parathyroid-implantation group appear to be somewhat stronger than parathyroid substance-given group though changes of both groups are less marked than control group.
4) It is, therefore, concluded that parthyroid gland and parathyroid substance are acting inhibitory upon the allergic changs of peripheral nerve.
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